Medication Monday: Rexulti

Welcome to another installment of Medication Monday, the weekly series that offers a brief informative introduction to the various mental health medications that are available (yes, for those of you no longer keeping track of the days, today is Monday). This week, the medication we are looking at is Rexulti (Brexpiprazole).

Rexulti is a second-generation antipsychotic, also known as an atypical antipsychotic. It is primarily used to treat schizophrenia, but can also be used in conjunction with other antidepressants to treat major depressive disorder. Users should know that antidepressants may increase the levels and effects of Rexulti. Antifungals and the antibiotic clarithromycin (Biaxin) may also increase the levels and effects of Rexulti.

It may take several weeks to several months to fully feel the effects of Rexulti. During this time it is very important to communicate any changes you experience to your doctor or psychopharmacologist so they can best decide if this medication is right for you. While everyone will be different, the timeline of effectiveness for those taking this medication for schizophrenia generally begins with hallucinations, disorganized thinking, delusions, motivation, and social desires possibly improving in the first 1-2 weeks. Symptoms will continue to improve the longer the medication is taken.

It should also be noted that as with almost all mental health medications, there are certain possible side effects that should be known. These include acid reflux (heartburn), cholesterol abnormalities, restlessness, and weight gain. This medication can also in certain cases cause a dangerous drop in one’s blood pressure. Inform your doctor right away if you experience such an effect.

As always, I am not a medical doctor and Medication Monday is not meant to be a substitute for medical advice. Any questions about Rexulti or any of the other medications featured in this series should go to your doctor or health care professional. Medication Monday is meant to help you be more informed about the options that are available to you, while also hopefully destigmatizing mental health medications altogether.

And as always, thanks for reading.

Sources: NAMI – Brexpiprazole (Rexulti); WebMD – Rexulti

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